Failure of 2″-deoxycoformycin to protect against transient forebrain ischemia in rat

S. M. Delaney, G. R. Sutherland, J. Peeling, J. D. Geiger

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We determined whether 2′-deoxycoformycin (DCF), a potent highly specific inhibitor of adenosine deaminase (ADA), protected against transient forebrain ischemic neuronal injury in rat. Anesthetized male Sprague-Dawley rats received i.p. injections of either saline, 0.5 mg/kg or 5 mg/kg DCF 2 h before undergoing a 10-min forebrain ischemic insult induced by bilateral carotid artery occlusion with concomitant hypotension. Rat brain sections taken 7 days post-ischemia showed damage mostly in the CA1 region of the hippocampus. Quantification of neuronal injury showed no significant differences between saline- or DCF-treated rats. These results indicate that, contrary to previous reports, DCF does not protect against the neuronal damage that follows forebrain ischemia in rat.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalNeuroscience Letters
Volume149
Issue number1
DOIs
StatePublished - Jan 4 1993
Externally publishedYes

Keywords

  • 2′-Deoxycoformycin
  • Adenosine
  • Adenosine deaminase
  • Cerebral ischemia
  • Histopathology

ASJC Scopus subject areas

  • Neuroscience(all)

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