Familial bleeding tendency associated with microcytic platelets and impaired release of platelet adenosine diphosphate

Harold M. Maurer; W. J.S. Still; Joyce Caul; Orestes S. Valdes; William E. Laupus

doi:10.1016/S0022-3476(71)80268-8

Familial bleeding tendency associated with microcytic platelets and impaired release of platelet adenosine diphosphate

Harold M. Maurer, W. J.S. Still, Joyce Caul, Orestes S. Valdes, William E. Laupus

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

This report describes a familial bleeding tendency associated with abnormal platelet responses to adenosine diphosphate (ADP), connective tissue suspension, thrombin, and kaolin, which were attributed to impaired platelet ADP release. All but one of the patients also had microcytic platelets. The association of microcytic platelets with impaired platelet ADP release may be due to a population of predominantly old platelets in these patients.

Original language	English (US)
Pages (from-to)	86-94
Number of pages	9
Journal	The Journal of Pediatrics
Volume	78
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(71)80268-8
State	Published - Jan 1971
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Familial bleeding tendency associated with microcytic platelets and impaired release of platelet adenosine diphosphate",

abstract = "This report describes a familial bleeding tendency associated with abnormal platelet responses to adenosine diphosphate (ADP), connective tissue suspension, thrombin, and kaolin, which were attributed to impaired platelet ADP release. All but one of the patients also had microcytic platelets. The association of microcytic platelets with impaired platelet ADP release may be due to a population of predominantly old platelets in these patients.",

author = "Maurer, {Harold M.} and Still, {W. J.S.} and Joyce Caul and Valdes, {Orestes S.} and Laupus, {William E.}",

note = "Funding Information: Pathology, Medical College of Virginia. Statistical analyses were supported in part by Public Health Research Grant RR 00016-08 from The National Institutes of Health.",

year = "1971",

month = jan,

doi = "10.1016/S0022-3476(71)80268-8",

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journal = "The Journal of Pediatrics",

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T1 - Familial bleeding tendency associated with microcytic platelets and impaired release of platelet adenosine diphosphate

AU - Maurer, Harold M.

AU - Still, W. J.S.

AU - Caul, Joyce

AU - Valdes, Orestes S.

AU - Laupus, William E.

N1 - Funding Information: Pathology, Medical College of Virginia. Statistical analyses were supported in part by Public Health Research Grant RR 00016-08 from The National Institutes of Health.

PY - 1971/1

Y1 - 1971/1

N2 - This report describes a familial bleeding tendency associated with abnormal platelet responses to adenosine diphosphate (ADP), connective tissue suspension, thrombin, and kaolin, which were attributed to impaired platelet ADP release. All but one of the patients also had microcytic platelets. The association of microcytic platelets with impaired platelet ADP release may be due to a population of predominantly old platelets in these patients.

AB - This report describes a familial bleeding tendency associated with abnormal platelet responses to adenosine diphosphate (ADP), connective tissue suspension, thrombin, and kaolin, which were attributed to impaired platelet ADP release. All but one of the patients also had microcytic platelets. The association of microcytic platelets with impaired platelet ADP release may be due to a population of predominantly old platelets in these patients.

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JO - The Journal of Pediatrics

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IS - 1

ER -

Familial bleeding tendency associated with microcytic platelets and impaired release of platelet adenosine diphosphate

Abstract

ASJC Scopus subject areas

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