Familial canine dermatomyositis: clinicopathologic, immunologic, and serologic studies.

K. H. Haupt, D. J. Prieur, A. M. Hargis, R. L. Cowell, T. L. McDonald, L. L. Werner, J. F. Evermann

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Laboratory studies were performed on 3 Collies with familial canine dermatomyositis, 6 progeny from a breeding of 2 of the Collies (incross litter), and 4 progeny from the breeding of an affected Collie male and a normal Labrador Retriever (outcross litter). Hematologic abnormalities were leukogram changes consistent with inflammation, and, in 2 severely affected incross dogs, anemia of inflammatory disease. Serum muscle enzyme activities were not markedly increased. High concentrations of immune complexes and proportionally increased total immunoglobulin G were present in the sera of moderately and severely affected incross dogs. The same dogs had weakly positive direct Coombs' tests, and 1 affected outcross dog had a strongly positive direct Coombs' test. Rheumatoid factor was present in a severely affected incross dog. A few dogs had polyclonal globulin increases that were attributed to inflammation. Low antibody titers to canine calicivirus were present in 3 dogs and a low titer to canine coronavirus was present in 1 dog.

Original languageEnglish (US)
Pages (from-to)1870-1875
Number of pages6
JournalAmerican journal of veterinary research
Issue number9
StatePublished - Sep 1985
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


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