Familial colon cancer in the Tel‐Aviv area and the influence of ethnic origin

Paul Rozen, Henry T. Lynch, Arie Figer, Shulamit Rozen, Zvi Fireman, Cyril Legum, Leah Katz, Alan Moy, William Kimberling, Jane Lynch, Patrice Watson

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The family history of colon cancer was investigated in 38,823 individuals (2,129 families) who comprised a control and an oncology patient series from Tel‐Aviv and nearby areas. A significant increased risk for colon cancer was observed among first‐degree relatives of colon cancer patients when compared to controls. When the patient sample was divided into two groups based on country and continent of birth—European (Ashkenazim) and other (non Ashkenazim)—the relatives of the nonAshkenazi subjects showed a greater relative risk for colon cancer (P < 0.05). Colon cancer was found to be less frequent in nonAshkenazim than in Ashkenazim controls. These findings suggest that although the colon cancer frequency in the nonAshkenazi group is lower, the genetic component may be more important than for the Ashkenazi sample. The nonAshkenazi Jews may represent distinct subgroups that differ with respect to either primary genetic susceptibility to colorectal cancer and/or they may have been subjected to peculiar, environmental carcinogenic exposures when compared to their Ash‐kenazim brethren.

Original languageEnglish (US)
Pages (from-to)2355-2359
Number of pages5
Issue number9
StatePublished - Nov 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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