Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum

Daniel D. Mosel, Raluca Dumitru, Jacob M. Hornby, Audrey L. Atkin, Kenneth W. Nickerson

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 μM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 μM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.

Original languageEnglish (US)
Pages (from-to)4938-4940
Number of pages3
JournalApplied and environmental microbiology
Volume71
Issue number8
DOIs
StatePublished - Aug 1 2005

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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