Fast functionalization of ultrasound microbubbles using strain promoted click chemistry

Xifeng Liu, Ping Gong, Pengfei Song, Feng Xie, A. Lee Miller, Shigao Chen, Lichun Lu

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Functionalization of microbubbles (MBs) is a difficult issue due to their unstable nature. Here we report a fast and versatile method using a strain promoted alkyne-azide cycloaddition (SPAAC) click reaction for microbubble functionalization. An azadibenzocyclooctyne (DBCO) group was first introduced onto the MB surface and then an azide group into the desired ligand. Without any initiators or catalysts, essential click ligation occurred within 1 min and a majority of the reaction completed in 5 min at 37 °C. This fast ligation shortens the microbubble reaction time and preserves essential amounts of microbubbles for further in situ imaging and delivery of therapeutics.

Original languageEnglish (US)
Pages (from-to)623-632
Number of pages10
JournalBiomaterials Science
Volume6
Issue number3
DOIs
StatePublished - Mar 2018

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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