Fat-soluble nutrients and Omega-3 fatty acids as modifiable factors influencing preterm birth risk

Melissa Thoene, Matthew Van Ormer, Ana Yuil-Valdes, Taylor Bruett, Sathish Kumar Natarajan, Maheswari Mukherjee, Maranda Thompson, Tara M. Nordgren, Wendy Van Lippevelde, Nina C. Overby, Kwame Adu-Bonsaffoh, Ann Anderson-Berry, Corrine Hanson

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Preterm birth is a leading cause of child morbidity and mortality, so strategies to reduce early birth must remain a priority. One key approach to enhancing birth outcomes is improving maternal dietary intake. Therefore, the purpose of this review is to discuss mechanisms on perinatal status of fat-soluble nutrients (carotenoids, retinol, tocopherols) and omega-3 fatty acids and how they impact risk for preterm birth. Literature review demonstrates that maternal dietary intake and biological (blood and placental tissue) levels of fat-soluble nutrients during pregnancy may provide antioxidative, anti-inflammatory, and immunomodulatory health benefits. Omega-3 fatty acids also promote increased production of specialized pro-resolving mediators, subsequently mediating inflammation resolution. Combined effects of these nutrients support appropriate placental organogenesis and function. Consequently, fat-soluble nutrients and omega-3 fatty acids serve as strong influencers for preterm birth risk. As dietary intake remains a modifiable factor, future intervention would benefit from a focus on optimizing perinatal status of these specific nutrients.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
StatePublished - Sep 1 2020


  • Carotenoid
  • Omega-3
  • Placenta
  • Preterm birth
  • Retinol
  • Tocopherol

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology


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