TY - JOUR
T1 - Fat-soluble nutrients and Omega-3 fatty acids as modifiable factors influencing preterm birth risk
AU - Thoene, Melissa
AU - Van Ormer, Matthew
AU - Yuil-Valdes, Ana
AU - Bruett, Taylor
AU - Natarajan, Sathish Kumar
AU - Mukherjee, Maheswari
AU - Thompson, Maranda
AU - Nordgren, Tara M.
AU - Van Lippevelde, Wendy
AU - Overby, Nina C.
AU - Adu-Bonsaffoh, Kwame
AU - Anderson-Berry, Ann
AU - Hanson, Corrine
N1 - Funding Information:
The project described was supported by the Nebraska Center for Prevention of Obesity Diseases, the National Institute of General Medical Sciences Grant (P20GM104320 to SKN, AAB, CH, TMN), the National Institute of Environmental Health Sciences (R00ES025819, TMN), the Nebraska Agricultural Experimental Station with funding from the Hatch Act (Accession Number 1014526 to SKN) through the United States Department of Agriculture, National Institute of Food and Agriculture (USDA-NIFA), the University of Nebraska-Lincoln, the University of Nebraska Collaboration Initiative (MM), Pediatric Research Fund of the Department of Pediatrics at the University of Nebraska Medical Center and Children's Hospital & Medical Center (MT*), and NIMHD of the National Institutes of Health under award number 1P50MD010431-01 (CH).
Funding Information:
The project described was supported by the Nebraska Center for Prevention of Obesity Diseases, the National Institute of General Medical Sciences Grant ( P20GM104320 to SKN, AAB, CH, TMN), the National Institute of Environmental Health Sciences ( R00ES025819 , TMN), the Nebraska Agricultural Experimental Station with funding from the Hatch Act (Accession Number 1014526 to SKN) through the United States Department of Agriculture , National Institute of Food and Agriculture (USDA-NIFA), the University of Nebraska-Lincoln, the University of Nebraska Collaboration Initiative (MM), Pediatric Research Fund of the Department of Pediatrics at the University of Nebraska Medical Center and Children's Hospital & Medical Center (MT*), and NIMHD of the National Institutes of Health under award number 1P50MD010431-01 (CH).
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Preterm birth is a leading cause of child morbidity and mortality, so strategies to reduce early birth must remain a priority. One key approach to enhancing birth outcomes is improving maternal dietary intake. Therefore, the purpose of this review is to discuss mechanisms on perinatal status of fat-soluble nutrients (carotenoids, retinol, tocopherols) and omega-3 fatty acids and how they impact risk for preterm birth. Literature review demonstrates that maternal dietary intake and biological (blood and placental tissue) levels of fat-soluble nutrients during pregnancy may provide antioxidative, anti-inflammatory, and immunomodulatory health benefits. Omega-3 fatty acids also promote increased production of specialized pro-resolving mediators, subsequently mediating inflammation resolution. Combined effects of these nutrients support appropriate placental organogenesis and function. Consequently, fat-soluble nutrients and omega-3 fatty acids serve as strong influencers for preterm birth risk. As dietary intake remains a modifiable factor, future intervention would benefit from a focus on optimizing perinatal status of these specific nutrients.
AB - Preterm birth is a leading cause of child morbidity and mortality, so strategies to reduce early birth must remain a priority. One key approach to enhancing birth outcomes is improving maternal dietary intake. Therefore, the purpose of this review is to discuss mechanisms on perinatal status of fat-soluble nutrients (carotenoids, retinol, tocopherols) and omega-3 fatty acids and how they impact risk for preterm birth. Literature review demonstrates that maternal dietary intake and biological (blood and placental tissue) levels of fat-soluble nutrients during pregnancy may provide antioxidative, anti-inflammatory, and immunomodulatory health benefits. Omega-3 fatty acids also promote increased production of specialized pro-resolving mediators, subsequently mediating inflammation resolution. Combined effects of these nutrients support appropriate placental organogenesis and function. Consequently, fat-soluble nutrients and omega-3 fatty acids serve as strong influencers for preterm birth risk. As dietary intake remains a modifiable factor, future intervention would benefit from a focus on optimizing perinatal status of these specific nutrients.
KW - Carotenoid
KW - Omega-3
KW - Placenta
KW - Preterm birth
KW - Retinol
KW - Tocopherol
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U2 - 10.1016/j.placenta.2019.12.002
DO - 10.1016/j.placenta.2019.12.002
M3 - Review article
C2 - 33039030
AN - SCOPUS:85076467864
SN - 0143-4004
VL - 98
SP - 38
EP - 42
JO - Placenta
JF - Placenta
ER -