FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.

Jawed A Siddiqui

doi:10.1038/s41388-019-0791-9

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.

Jawed A Siddiqui

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Farnesyl diphosphate synthase (FDPS), a mevalonate pathway enzyme, is highly expressed in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional, and clinical significance of FDPS in cancer remains unexplored. We evaluated the FDPS expression and its cancer-associated phenotypes using in vitro and in vivo methods in PTEN-deficient and sufficient human and mouse PCa cells and tumors. Interestingly, FDPS overexpression synergizes with PTEN deficiency in PTEN conditionally knockout mice (P

Original language	English (US)
Journal	Oncogene
DOIs	https://doi.org/10.1038/s41388-019-0791-9
State	Published - Mar 26 2019

Access to Document

10.1038/s41388-019-0791-9

Cite this

@article{1ef0f5e2f68a453fb8f515ee6d4cd2ed,

title = "FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.",

abstract = "Farnesyl diphosphate synthase (FDPS), a mevalonate pathway enzyme, is highly expressed in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional, and clinical significance of FDPS in cancer remains unexplored. We evaluated the FDPS expression and its cancer-associated phenotypes using in vitro and in vivo methods in PTEN-deficient and sufficient human and mouse PCa cells and tumors. Interestingly, FDPS overexpression synergizes with PTEN deficiency in PTEN conditionally knockout mice (P ",

author = "Siddiqui, {Jawed A}",

year = "2019",

month = mar,

day = "26",

doi = "10.1038/s41388-019-0791-9",

language = "English (US)",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Springer Nature",

}

TY - JOUR

T1 - FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.

AU - Siddiqui, Jawed A

PY - 2019/3/26

Y1 - 2019/3/26

N2 - Farnesyl diphosphate synthase (FDPS), a mevalonate pathway enzyme, is highly expressed in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional, and clinical significance of FDPS in cancer remains unexplored. We evaluated the FDPS expression and its cancer-associated phenotypes using in vitro and in vivo methods in PTEN-deficient and sufficient human and mouse PCa cells and tumors. Interestingly, FDPS overexpression synergizes with PTEN deficiency in PTEN conditionally knockout mice (P

AB - Farnesyl diphosphate synthase (FDPS), a mevalonate pathway enzyme, is highly expressed in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional, and clinical significance of FDPS in cancer remains unexplored. We evaluated the FDPS expression and its cancer-associated phenotypes using in vitro and in vivo methods in PTEN-deficient and sufficient human and mouse PCa cells and tumors. Interestingly, FDPS overexpression synergizes with PTEN deficiency in PTEN conditionally knockout mice (P

UR - https://europepmc.org/articles/PMC6597298

U2 - 10.1038/s41388-019-0791-9

DO - 10.1038/s41388-019-0791-9

M3 - Article

C2 - 30914801

SN - 0950-9232

JO - Oncogene

JF - Oncogene

ER -

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.

Abstract

Access to Document

Other files and links

Fingerprint

Cite this