Fecal short-chain fatty acid concentrations increase in newly paired male marmosets (Callithrix jacchus)

Lifeng Zhu, Mallory J.Suhr Van Haute, Haley R. Hassenstab, Caroline Smith, Devin J. Rose, Aaryn C. Mustoe, Andrew K. Benson, Jeffrey A. French

Research output: Contribution to journalArticlepeer-review

Abstract

The role by which the gut microbiome influences host health (e.g., energy equilibrium and immune system) may be partly mediated by short-chain fatty acids, which are bacterial fermentation products from the dietary fibers. However, little is known about longitudinal changes in gut microbiome metabolites during cohabitation alongside social contact. In common marmosets (Callithrix jacchus), the gut microbiome community is influenced by social contact, as newly paired males and females develop convergent microbial profiles. Here, we monitored the dynamics of short-chain fatty acid concentrations in common marmoset feces from the prepairing (PRE) to postpairing (POST) stages. In males, we observed that the concentrations of acetate, propionate, isobutyrate, and isovalerate significantly increased in the POST stage compared to the PRE stage. However, no significant changes were found in females. We further found that the propionate concentration was significantly positively correlated with the abundance of Phascolarctobacterium in the male feces. Thus, the sex difference in the changes in the concentrations of short-chain fatty acids might be related to sex-biased gut microbiome transmission after pairing. We suggest that the significant changes in the gut microbiomes and some shortchain fatty acids of the common marmoset during cohabitation may contribute to physiological homeostasis during pairing.

Original languageEnglish (US)
Article number794
JournalmSphere
Volume5
Issue number5
DOIs
StatePublished - Sep 2020

Keywords

  • Cohabitation and social contact
  • Common marmosets
  • Sex difference
  • Short-chain fatty acids

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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