Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury

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2 Scopus citations

Abstract

Ferroptosis is a type of programmed cell death caused by phospholipid peroxidation that has been implicated as a mechanism in several diseases resulting from ischemic-reperfusion injury. Most recently, ferroptosis has been identified as a possible key injury mechanism in neonatal hypoxic-ischemic brain injury (HIBI). This review summarizes the current literature regarding the different ferroptotic pathways, how they may be activated after neonatal HIBI, and which current or investigative interventions may attenuate ferroptotic cell death associated with neonatal HIBI.

Original languageEnglish (US)
Article number7420
JournalInternational journal of molecular sciences
Volume23
Issue number13
DOIs
StatePublished - Jul 1 2022

Keywords

  • FSP1
  • GPX4
  • asphyxia
  • encephalopathy
  • glutathione
  • iron free radicals
  • neuroprotection
  • phospholipid peroxidation

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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