Fetal alcohol syndrome and secondary schizophrenia: A unique neuropathologic study

Catherine Stoos, Laura Nelsen, Kathryn A. Schissler, Amy J. Elliott, Hannah C. Kinney

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We report the unique neuropathologic study of an adult brain of a patient with fetal alcohol syndrome who developed the well-recognized complication of schizophrenia in adolescence. The major finding was asymmetric formation of the lateral temporal lobes, with marked enlargement of the right superior temporal gyrus, suggesting that alcohol is preferentially toxic to temporal lobe patterning during gestation. Critical maturational changes unique to adolescence can unmask psychotic symptomatology mediated by temporal lobe pathology that has been clinically dormant since birth. Elucidating the neuropathologic basis of the secondary psychiatric disorders in fetal alcohol syndrome can help provide insight into their putative developmental origins.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalJournal of Child Neurology
Volume30
Issue number5
DOIs
StatePublished - Apr 27 2015

Keywords

  • areal patterning
  • schizophrenia
  • superior temporal gyrus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Fetal alcohol syndrome and secondary schizophrenia: A unique neuropathologic study'. Together they form a unique fingerprint.

  • Cite this