TY - JOUR
T1 - Fiber-based tissue engineering
T2 - Progress, challenges, and opportunities
AU - Tamayol, Ali
AU - Akbari, Mohsen
AU - Annabi, Nasim
AU - Paul, Arghya
AU - Khademhosseini, Ali
AU - Juncker, David
N1 - Funding Information:
Financial support from NSERC , CIHR , CHRP , CFI , Genome Canada , and Genome Quebec is gratefully acknowledged. A.T. and M.A. acknowledge NSERC Postdoctoral fellowships. D.J. acknowledges support from a Canada Research Chair . The authors declare no conflict of interests in this work. A.K. acknowledges funding from the National Science Foundation Career Award ( DMR 0847287 ), the office of Naval Research Young National Investigator Award , and the National Institutes of Health ( HL092836 , DE019024 , EB012597 , AR057837 , DE021468 , HL099073 , EB008392 ). A.P. acknowledges NSERC – Michael Smith Foreign Study Canada Graduate Scholarship and Postdoctoral award from Fonds Québécois de la Recherche sur la Nature et les Technologies (FRSQ, Canada).
PY - 2013/9
Y1 - 2013/9
N2 - Tissue engineering aims to improve the function of diseased or damaged organs by creating biological substitutes. To fabricate a functional tissue, the engineered construct should mimic the physiological environment including its structural, topographical, and mechanical properties. Moreover, the construct should facilitate nutrients and oxygen diffusion as well as removal of metabolic waste during tissue regeneration. In the last decade, fiber-based techniques such as weaving, knitting, braiding, as well as electrospinning, and direct writing have emerged as promising platforms for making 3D tissue constructs that can address the abovementioned challenges. Here, we critically review the techniques used to form cell-free and cell-laden fibers and to assemble them into scaffolds. We compare their mechanical properties, morphological features and biological activity. We discuss current challenges and future opportunities of fiber-based tissue engineering (FBTE) for use in research and clinical practice.
AB - Tissue engineering aims to improve the function of diseased or damaged organs by creating biological substitutes. To fabricate a functional tissue, the engineered construct should mimic the physiological environment including its structural, topographical, and mechanical properties. Moreover, the construct should facilitate nutrients and oxygen diffusion as well as removal of metabolic waste during tissue regeneration. In the last decade, fiber-based techniques such as weaving, knitting, braiding, as well as electrospinning, and direct writing have emerged as promising platforms for making 3D tissue constructs that can address the abovementioned challenges. Here, we critically review the techniques used to form cell-free and cell-laden fibers and to assemble them into scaffolds. We compare their mechanical properties, morphological features and biological activity. We discuss current challenges and future opportunities of fiber-based tissue engineering (FBTE) for use in research and clinical practice.
KW - Cell-laden constructs
KW - Fiber-based techniques
KW - Scaffold fabrication
KW - Tissue engineering
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U2 - 10.1016/j.biotechadv.2012.11.007
DO - 10.1016/j.biotechadv.2012.11.007
M3 - Review article
C2 - 23195284
AN - SCOPUS:84879412130
VL - 31
SP - 669
EP - 687
JO - Biotechnology Advances
JF - Biotechnology Advances
SN - 0734-9750
IS - 5
ER -