Fiber-based tissue engineering: Progress, challenges, and opportunities

Ali Tamayol, Mohsen Akbari, Nasim Annabi, Arghya Paul, Ali Khademhosseini, David Juncker

Research output: Contribution to journalReview articlepeer-review

350 Scopus citations


Tissue engineering aims to improve the function of diseased or damaged organs by creating biological substitutes. To fabricate a functional tissue, the engineered construct should mimic the physiological environment including its structural, topographical, and mechanical properties. Moreover, the construct should facilitate nutrients and oxygen diffusion as well as removal of metabolic waste during tissue regeneration. In the last decade, fiber-based techniques such as weaving, knitting, braiding, as well as electrospinning, and direct writing have emerged as promising platforms for making 3D tissue constructs that can address the abovementioned challenges. Here, we critically review the techniques used to form cell-free and cell-laden fibers and to assemble them into scaffolds. We compare their mechanical properties, morphological features and biological activity. We discuss current challenges and future opportunities of fiber-based tissue engineering (FBTE) for use in research and clinical practice.

Original languageEnglish (US)
Pages (from-to)669-687
Number of pages19
JournalBiotechnology Advances
Issue number5
StatePublished - Sep 2013
Externally publishedYes


  • Cell-laden constructs
  • Fiber-based techniques
  • Scaffold fabrication
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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