@article{8c1fdf55898b404baf745281d5b902c6,
title = "Fibroblasts: The arbiters of extracellular matrix remodeling",
abstract = "Extracellular matrix (ECM) is the foundation on which all cells and organs converge to orchestrate normal physiological functions. In the setting of pathology, the ECM is modified to incorporate additional roles, with modifications including turnover of existing ECM and deposition of new ECM. The fibroblast is center stage in coordinating both normal tissue homeostasis and response to disease. Understanding how fibroblasts work under normal conditions and are activated in response to injury or stress will provide mechanistic insight that triggers discovery of new therapeutic treatments for a wide range of disease. We highlight here fibroblast roles in the cancer, lung, and heart as example systems where fibroblasts are major contributors to homeostasis and pathology.",
author = "DeLeon-Pennell, {Kristine Y.} and Barker, {Thomas H.} and Lindsey, {Merry L.}",
note = "Funding Information: Dr. Lindsey is a Stokes-Shackleford Professor at UNMC. We acknowledge funding from National Institutes of Health under Award Numbers R13HL149435 , U54DA016511 , HL075360 , HL127283 , HL129823 , HL132585 , and HL137319 , and from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development under Award Numbers 5I01BX000505 and IK2BX003922 . This work was also financially supported, in part, by the 2019 S&R Foundation Ryuji Ueno Award that was bestowed upon KYD-P by the American Physiological Society . The content is solely the responsibility of the authors and does not necessarily represent the official views of any of the funding agencies. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2020",
month = sep,
doi = "10.1016/j.matbio.2020.05.006",
language = "English (US)",
volume = "91-92",
pages = "1--7",
journal = "Matrix Biology",
issn = "0945-053X",
publisher = "Elsevier",
}