Fibrogenesis in primary myelofibrosis: Diagnostic, clinical, and therapeutic implications

Aziz Nazha, Joseph D. Khoury, Raajit K. Rampal, Naval Daver

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Primary myelofibrosis is a stem cell-derived clonal malignancy characterized by unchecked proliferation of myeloid cells, resulting in bone marrow fibrosis, osteosclerosis, and pathologic angiogenesis. Bone marrow fibrosis (BMF) plays a central role in the pathophysiology of the disease. This review describes current issues regarding BMF in primary myelofibrosis, including the pathophysiology and impact of abnormal deposition of excess collagen and reticulin fibers in bone marrow spaces, the modified Bauermeister and the European Consensus grading systems of BMF, and the prognostic impact of BMF on the overall outcome of patients with primary myelofibrosis. The impact of novel therapeutic strategies, including JAK-STAT inhibitors and allogeneic stem cell transplant, on BMF is discussed.

Original languageEnglish (US)
Pages (from-to)1154-1160
Number of pages7
Issue number10
StatePublished - Aug 24 2015
Externally publishedYes


  • Bone marrow fibrosis
  • Collagen fibrosis
  • Primary myelofibrosis
  • Reticulin fibrosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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