Filamentation involves two overlapping, but Distinct, programs of filamentation in the pathogenic fungus Candida albicans

Jahaun Azadmanesh, Austin M. Gowen, Paul E. Creger, Nichole D. Schafer, Jill R. Blankenship

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The ability of the human pathogenic fungus Candida albicans to switch between yeast-like and filamentous forms of growth has long been linked to pathogenesis. Numerous environmental conditions, including growth at high temperatures, nutrient limitation, and exposure to serum, can trigger this morphological switch and are frequently used in in vitro models to identify genes with roles in filamentation. Previous work has suggested that differences exist between the various in vitro models both in the genetic requirements for filamentation and transcriptional responses to distinct filamentation-inducing media, but these differences had not been analyzed in detail. We compared 10 in vitro models for filamentation and found broad genetic and transcriptomic differences between model systems. The comparative analysis enabled the discovery of novel media-independent genetic requirements for filamentation as well as a core filamentation transcriptional profile. Our data also suggest that the physical environment drives distinct programs of filamentation in C. albicans, which has significant implications for filamentation in vivo.

Original languageEnglish (US)
Pages (from-to)3797-3808
Number of pages12
JournalG3: Genes, Genomes, Genetics
Volume7
Issue number11
DOIs
StatePublished - Nov 1 2017

Keywords

  • Candida albicans
  • Comparisons
  • Filamentation
  • Hyphal growth
  • In vitro model

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Filamentation involves two overlapping, but Distinct, programs of filamentation in the pathogenic fungus Candida albicans'. Together they form a unique fingerprint.

Cite this