First results of digital topography applied to macromolecular crystals

Jeffrey J. Lovelace, Alexei S. Soares, Henry D. Bellamy, Robert M. Sweet, Edward H. Snell, Gloria E.O. Borgstahl

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


An inexpensive digital CCD camera was used to record X-ray topographs directly from large imperfect crystals of cubic insulin. The topographs recorded were not as detailed as those which can be measured with film or emulsion plates, but do show great promise. Six reflections were recorded using a set of finely spaced stills encompassing the rocking curve of each reflection. A complete topographic reflection profile could be digitally imaged in minutes. Interesting and complex internal structure was observed by this technique. The CCD chip used in the camera has anti-blooming circuitry and produced good data quality, even when pixels became overloaded.

Original languageEnglish (US)
Pages (from-to)481-485
Number of pages5
JournalJournal of Applied Crystallography
Issue number3
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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