First use of investigational antiviral drug pocapavir (V-073) for treating neonatal enteroviral sepsis

Sanet Torres-Torres; Angela L. Myers; J. Michael Klatte; Eric E. Rhoden; M. Steven Oberste; Marc S. Collett; Russell J. McCulloh

doi:10.1097/INF.0000000000000497

First use of investigational antiviral drug pocapavir (V-073) for treating neonatal enteroviral sepsis

Sanet Torres-Torres, Angela L. Myers, J. Michael Klatte, Eric E. Rhoden, M. Steven Oberste, Marc S. Collett, Russell J. McCulloh

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3.

Original language	English (US)
Pages (from-to)	52-54
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	34
Issue number	1
DOIs	https://doi.org/10.1097/INF.0000000000000497
State	Published - 2015
Externally published	Yes

Keywords

Coxsackievirus
Neonatal enterovirus infection
Pocapavir

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0000000000000497

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title = "First use of investigational antiviral drug pocapavir (V-073) for treating neonatal enteroviral sepsis",

abstract = "Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3.",

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AU - Torres-Torres, Sanet

AU - Myers, Angela L.

AU - Klatte, J. Michael

AU - Rhoden, Eric E.

AU - Oberste, M. Steven

AU - Collett, Marc S.

AU - McCulloh, Russell J.

PY - 2015

Y1 - 2015

N2 - Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3.

AB - Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3.

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KW - Neonatal enterovirus infection

KW - Pocapavir

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First use of investigational antiviral drug pocapavir (V-073) for treating neonatal enteroviral sepsis

Abstract

Keywords

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