Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice

Ganesh V. Halade, Paul J. Williams, Merry L. Lindsey, Gabriel Fernandes

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Clinical studies suggest that rosiglitazone (RSG) treatment may increase the incidence of heart failure in diabetic patients. In this study, we examined whether a high corn oil diet with RSG treatment in insulin resistant aging mice exerted metabolic and pro-inflammatory effects that stimulate cardiac dysfunction. We also evaluated whether fish oil attenuated these effects. Female C57BL/6J mice (13 months old) were divided into 5 groups: (1) lean control (LC), (2) corn oil, (3) fish oil, (4) corn oil + RSG and (5) fish oil + RSG. Mice fed a corn oil enriched diet and RSG developed hypertrophy of the left ventricle (LV) and decreased fractional shortening, despite a significant increase in total body lean mass. In contrast, LV hypertrophy was prevented in RSG treated mice fed a fish oil enriched diet. Importantly, hyperglycemia was controlled in both RSG groups. Further, fish oil + RSG decreased LV expression of atrial and brain natriuretic peptides, fibronectin and the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α, concomitant with increased interleukin-10 and adiponectin levels compared to the corn oil + RSG group. Fish oil + RSG treatment suppressed inflammation, increased serum adiponectin, and improved fractional shortening, attenuating the cardiac remodeling seen in the corn oil + RSG diet fed C57BL/6J insulin resistant aging mice. Our results suggest that RSG treatment has context-dependent effects on cardiac remodeling and serves a negative cardiac role when given with a corn oil enriched diet.

Original languageEnglish (US)
Pages (from-to)300-307
Number of pages8
JournalPharmacological Research
Volume63
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • Aging
  • Cardiac remodeling
  • Corn oil
  • Fish oil
  • Inflammation
  • Left ventricle hypertrophy
  • Rosiglitazone

ASJC Scopus subject areas

  • Pharmacology

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