TY - GEN
T1 - Flow characterization of microfluidic paper-based analytical devices with hollow channels
AU - Zhang, Haipeng
AU - Barmore, Danielle
AU - Ryu, Sangjin
N1 - Funding Information:
This study was supported by the Interdisciplinary Research Grant of the University of Nebraska-Lincoln and the Research Experiences for Undergraduate (REU) program of the National Science Foundation (grant# 1659777).
PY - 2019
Y1 - 2019
N2 - Microfluidic paper-based analytical devices (µPADs) are cost-effective point-of-care diagnostic devices. µPADs consist of porous filter paper patterned with hydrophobic solid ink barriers to create flow channels. Because a liquid sample flows through the paper channel driven by capillary force, the resultant flow is usually slow. To overcome this limitation, a hollow channel can be added to a µPAD to increase the flow speed significantly. The liquid flow through the hollow channel is known to be driven by a pressure difference between the inlet and outlet of the device. Accordingly, theoretical models have been proposed to understand and predict flow characteristics of µPADs with hollow channels. The goal of this study is to experimentally characterize liquid flow through µPADs having a hollow channel, by investigating relationships among the travel distance of the liquid front through the µPADs, the applied pressure difference, and the dimension of the hollow channel. Thus, the outcome of this study would contribute to validating the theoretical models and enable better control of liquid sample flow in µPADs with hollow channels.
AB - Microfluidic paper-based analytical devices (µPADs) are cost-effective point-of-care diagnostic devices. µPADs consist of porous filter paper patterned with hydrophobic solid ink barriers to create flow channels. Because a liquid sample flows through the paper channel driven by capillary force, the resultant flow is usually slow. To overcome this limitation, a hollow channel can be added to a µPAD to increase the flow speed significantly. The liquid flow through the hollow channel is known to be driven by a pressure difference between the inlet and outlet of the device. Accordingly, theoretical models have been proposed to understand and predict flow characteristics of µPADs with hollow channels. The goal of this study is to experimentally characterize liquid flow through µPADs having a hollow channel, by investigating relationships among the travel distance of the liquid front through the µPADs, the applied pressure difference, and the dimension of the hollow channel. Thus, the outcome of this study would contribute to validating the theoretical models and enable better control of liquid sample flow in µPADs with hollow channels.
KW - Capillary flow
KW - Poiseuille flow
KW - Pressure-driven flow
KW - Scaling law
KW - Washburn law
UR - http://www.scopus.com/inward/record.url?scp=85076495133&partnerID=8YFLogxK
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U2 - 10.1115/AJKFluids2019-5502
DO - 10.1115/AJKFluids2019-5502
M3 - Conference contribution
AN - SCOPUS:85076495133
T3 - ASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference, AJKFluids 2019
BT - Fluid Measurement and Instrumentation; Micro and Nano Fluid Dynamics
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference, AJKFluids 2019
Y2 - 28 July 2019 through 1 August 2019
ER -