Flt3 ligand: A novel cytokine prevents allergic asthma in a mouse model

Devendra K. Agrawal, Michael T. Hopfenspirger, Jennifer Chavez, James E. Talmadge

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Flt-3 ligand (FL), a recently described growth factor affecting early hematopoietic progenitor cells, can also support the expansion of dendritic cells secreting IL-12. Since type 2 T cells predominate in asthma and IL-12 prevents the differentiation of naive T lymphocytes to a type 2 phenotype, we hypothesized that FL could prevent the development of asthma-like conditions in the ovalbumin mouse model. We found that co-administration of FL during ovalbumin sensitization abrogated late allergic responses, but had no effect on early allergic responses. Airway hyperresponsiveness to methacholine was also blocked by FL treatment. Analysis of bronchoalveolar lavage (BAL) fluid demonstrated a significant reduction in eosinophils, with concomitant decreases in IL-5 and increases in IFN-γ levels. However, there was no change in BAL fluid IL-4 and serum IgE levels. These data suggest that FL treatment prevents ovalbumin-induced asthma in the mouse and may provide a useful adjuvant in the treatment of human asthma.

Original languageEnglish (US)
Pages (from-to)2081-2089
Number of pages9
JournalInternational Immunopharmacology
Volume1
Issue number12
DOIs
StatePublished - Oct 27 2001

Keywords

  • Airway hyperresponsiveness
  • Asthma
  • Eosinophilia
  • Flt-3 ligand
  • Late allergic response

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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