Flt3 ligand augmentation of T cell mitogenesis and expansion of type 1 effector/memory T cells

R. Lee Mosley, Prahlad Parajuli, Vladimir Pisarev, Jennifer Chavez, Amy Meeks, Amy Steffel, Cheryl Leutzinger, James E. Talmadge

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Herein we report mechanisms whereby Flt3 ligand (FL) augments steady state T cell activity in addition to the expansion of dendritic cells (DCs). We demonstrate that in vivo administration of FL increases the frequency and absolute number of effector/memory T cells and preferentially expands T cells that express a type-1 cytokine phenotype. In addition, FL enhances T cell proliferative responses to Concanavalin A that directly correlated with increased frequencies in effector/memory T cells and expansion of lymphoid-derived (type 1) DCs (DC1s). Together, these data demonstrate that mechanisms of FL-induced T cell regulation include not only the expansion of DC subsets, but also the preferential expansion of type 1-effector/memory T cell populations, and suggest multiple mechanisms of action for FL as a vaccine adjuvant and as a therapeutic modality.

Original languageEnglish (US)
Pages (from-to)925-940
Number of pages16
JournalInternational Immunopharmacology
Volume2
Issue number7
DOIs
StatePublished - 2002

Keywords

  • Dendritic cells
  • Flt3 ligand
  • Interferon-γ
  • Interleukin-4
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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