Fluid Flow Control of Stem Cells With Investigation of Mechanotransduction Pathways

Brandon D. Riehl, Henry J. Donahue, Jung Yul Lim

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Stem cells in vivo experience shear and chemotransport from fluid flow within mechanically active tissues and while migrating from niches to homing targets in the body. Fluid flow-based strategies in tissue engineering and regenerative medicine mimic the in vivo flow environments to expand and condition cells, to guide stem cell lineage commitment, to study stem cell migration in dynamic environments, and to condition engineered tissues and stimulate extracellular matrix production. Stem cells sense mechanical signals and translate them into appropriate biochemical activities through the process of mechanotransduction via cytoskeletal reorganization and cellular tension signaling, by the regulation of cell-substrate adhesion and cell-cell junctional proteins, and through related downstream signaling molecules. Investigation of mechanotransduction pathways will provide mechanistic insight for improving cell therapies and functional tissue engineering. This chapter discusses fluid flow regulation of stem cell proliferation, quiescence, differentiation, migration, and tissue remodeling with brief discussions of underlying molecular pathways.

Original languageEnglish (US)
Title of host publicationBiology and Engineering of Stem Cell Niches
PublisherElsevier Inc.
Pages257-272
Number of pages16
ISBN (Electronic)9780128027561
ISBN (Print)9780128027349
DOIs
StatePublished - Apr 14 2017

Keywords

  • Differentiation
  • Fluid flow
  • Functional tissue engineering
  • Mechanotransduction
  • Migration
  • Proliferation
  • Shear stress
  • Stem cell

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Fluid Flow Control of Stem Cells With Investigation of Mechanotransduction Pathways'. Together they form a unique fingerprint.

Cite this