Fluid mechanics and mass transport analysis in stenosed carotid arteries

Yutong Liu, H. Udaykumar, A. Nagaraj, A. Hamilton, D. D. McPherson, K. B. Chandran

Research output: Contribution to journalConference article

Abstract

The fluid dynamics distal to a stenosis in vivo, and its effect on mass transport of LDL and oxygen were analyzed through a computational simulation. The in vivo carotid artery stenosis was created by denuding the arterial intimal surface in a Yucatan miniswine atheroma model. The animals were then fed high cholesterol diet. After 8 weeks, images of the atheroma forming arterial segments were obtained using intravascular ultrasound (IVUS) and reconstructed into a three-dimensional mesh. The computational model included unsteady flow analysis with time varying inflow velocity and with the measured distensibility specified as boundary conditions, as well as LDL and oxygen transport analysis. The results indicated flow separation and reattachment distal to the stenosis. Mean wall shear stress was the highest at the stenosis throat and became negative at the flow re-circulation zone. In the high wall shear stress regions LDL accumulation was reduced while oxygen transport was increased. In the low wall shear regions, the reduced arterial flows enhanced LDL accumulation but at the same time decreased the oxygen concentration. The analysis indicated that regions distal to the stenosis with oxygen deprivation and enhanced LDL accumulation in low wall shear regions may result in further growth of atheroma.

Original languageEnglish (US)
Pages (from-to)1309-1310
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • LDL transport
  • Oxygen transport
  • Wall shear stress

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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