Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation

Madeline T. Olson, Quan P. Ly, Aaron M. Mohs

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


Surgical resection continues to function as the primary treatment option for most solid tumors. However, the detection of cancerous tissue remains predominantly subjective and reliant on the expertise of the surgeon. Surgery that is guided by fluorescence imaging has shown clinical relevance as a new approach to detecting the primary tumor, tumor margins, and metastatic lymph nodes. It is a technique to reduce recurrence and increase the possibility of a curative resection. While significant progress has been made in developing this emerging technology as a tool to assist the surgeon, further improvements are still necessary. Refining imaging agents and tumor targeting strategies to be a precise and reliable surgical strategy is essential in order to translate this technology into patient care settings. This review seeks to provide a comprehensive update on the most recent progress of fluorescence-guided surgery and its translation into the clinic. By highlighting the current status and recent developments of fluorescence image-guided surgery in the field of surgical oncology, we aim to offer insight into the challenges and opportunities that require further investigation.

Original languageEnglish (US)
Pages (from-to)200-218
Number of pages19
JournalMolecular Imaging and Biology
Issue number2
StatePublished - Apr 15 2019


  • Fluorescence
  • Image-guided surgery
  • Optical contrast agents
  • Optical surgical navigation
  • Surgical oncology

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


Dive into the research topics of 'Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation'. Together they form a unique fingerprint.

Cite this