Fluoxetine, smoking, and history of major depression: A randomized controlled trial

Bonnie Spring, Neal Doran, Sherry Pagoto, Dennis McChargue, Jessica Werth Cook, Katherine Bailey, John Crayton, Donald Hedeker

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p =.02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p =.02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalJournal of Consulting and Clinical Psychology
Issue number1
StatePublished - Feb 2007


  • Depression
  • Fluoxetine
  • Randomized controlled trial
  • Smoking cessation
  • Tobacco

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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