Fluxional additives: A second generation control in enantioselective catalysis

Mukund P. Sibi, Shankar Manyem, Hector Palencia

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The concept of "fluxional additives", additives that can adopt enantiomeric conformations depending on the chiral information in the ligand, is demonstrated in enantioselective Diels-Alder and nitrone cycloaddition reactions. The additive design is modular, and diverse structures are accessible in three steps. Chiral Lewis acids from main group and transition metals show enhancements in enantioselectivity in the presence of these additives.

Original languageEnglish (US)
Pages (from-to)13660-13661
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number42
DOIs
StatePublished - Oct 25 2006

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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