Fluxional additives: A second generation control in enantioselective catalysis

Mukund P. Sibi; Shankar Manyem; Hector Palencia

doi:10.1021/ja064472a

Fluxional additives: A second generation control in enantioselective catalysis

Mukund P. Sibi, Shankar Manyem, Hector Palencia

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The concept of "fluxional additives", additives that can adopt enantiomeric conformations depending on the chiral information in the ligand, is demonstrated in enantioselective Diels-Alder and nitrone cycloaddition reactions. The additive design is modular, and diverse structures are accessible in three steps. Chiral Lewis acids from main group and transition metals show enhancements in enantioselectivity in the presence of these additives.

Original language	English (US)
Pages (from-to)	13660-13661
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	42
DOIs	https://doi.org/10.1021/ja064472a
State	Published - Oct 25 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja064472a

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AB - The concept of "fluxional additives", additives that can adopt enantiomeric conformations depending on the chiral information in the ligand, is demonstrated in enantioselective Diels-Alder and nitrone cycloaddition reactions. The additive design is modular, and diverse structures are accessible in three steps. Chiral Lewis acids from main group and transition metals show enhancements in enantioselectivity in the presence of these additives.

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Fluxional additives: A second generation control in enantioselective catalysis

Abstract

ASJC Scopus subject areas

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