Folate-decorated nanogels for targeted therapy of ovarian cancer

Natalia V. Nukolova, Hardeep S. Oberoi, Samuel M. Cohen, Alexander V. Kabanov, Tatiana K. Bronich

Research output: Contribution to journalArticle

180 Scopus citations

Abstract

Nanogels are comprised of swollen polymer networks and nearly 95% water and can entrap diverse chemical and biological agents for cancer therapy with very high loading capacities. Here we use diblock copolymer poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) to form nanogels with the desired degree of cross-linking. The nanogels are further conjugated to folic acid (FA) and loaded with different types of drugs (cisplatin, doxorubicin). For the first time we demonstrate a tumor-specific delivery and superior anti-tumor effect in vivo of an anti-cancer drug using these polyelectrolyte nanogels decorated with folate-targeting groups. This reinforces the use of nanogels for the therapy of ovarian and other cancers, where folate receptor (FR) is overexpressed.

Original languageEnglish (US)
Pages (from-to)5417-5426
Number of pages10
JournalBiomaterials
Volume32
Issue number23
DOIs
StatePublished - Aug 2011

Keywords

  • Cisplatin
  • Drug delivery
  • Folate-targeting
  • Nanogel
  • Ovarian cancer

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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