Foscarnet for suppression of human immunodeficiency virus replication

C. V. Fletcher; A. C. Collier; F. S. Rhame; D. Bennett; M. F. Para; C. C. Beatty; C. E. Jones; H. H. Balfour

doi:10.1128/AAC.38.3.604

Foscarnet for suppression of human immunodeficiency virus replication

C. V. Fletcher, A. C. Collier, F. S. Rhame, D. Bennett, M. F. Para, C. C. Beatty, C. E. Jones, H. H. Balfour

Research output: Contribution to journal › Comment/debate › peer-review

31 Scopus citations

Abstract

The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4⁺ lymphocytes was 64 cells per mm³. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression was related to systemic foscarnet exposure by a maximum-effect pharmacodynamic model.

Original language	English (US)
Pages (from-to)	604-607
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	38
Issue number	3
DOIs	https://doi.org/10.1128/AAC.38.3.604
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.38.3.604

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abstract = "The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression was related to systemic foscarnet exposure by a maximum-effect pharmacodynamic model.",

author = "Fletcher, {C. V.} and Collier, {A. C.} and Rhame, {F. S.} and D. Bennett and Para, {M. F.} and Beatty, {C. C.} and Jones, {C. E.} and Balfour, {H. H.}",

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AU - Fletcher, C. V.

AU - Collier, A. C.

AU - Rhame, F. S.

AU - Bennett, D.

AU - Para, M. F.

AU - Beatty, C. C.

AU - Jones, C. E.

AU - Balfour, H. H.

PY - 1994

Y1 - 1994

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AB - The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression was related to systemic foscarnet exposure by a maximum-effect pharmacodynamic model.

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JF - Antimicrobial Agents and Chemotherapy

IS - 3

ER -

Foscarnet for suppression of human immunodeficiency virus replication

Abstract

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