FOXM1: A small fox that makes more tracks for cancer progression and metastasis

Md Arafat Khan; Parvez Khan; Aatiya Ahmad; Mahek Fatima; Mohd Wasim Nasser

doi:10.1016/j.semcancer.2023.03.007

FOXM1: A small fox that makes more tracks for cancer progression and metastasis

Md Arafat Khan, Parvez Khan, Aatiya Ahmad, Mahek Fatima, Mohd Wasim Nasser

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Transcription factors (TFs) are indispensable for the modulation of various signaling pathways associated with normal cell homeostasis and disease conditions. Among cancer-related TFs, FOXM1 is a critical molecule that regulates multiple aspects of cancer cells, including growth, metastasis, recurrence, and stem cell features. FOXM1 also impact the outcomes of targeted therapies, chemotherapies, and immune checkpoint inhibitors (ICIs) in various cancer types. Recent advances in cancer research strengthen the cancer-specific role of FOXM1, providing a rationale to target FOXM1 for developing targeted therapies. This review compiles the recent studies describing the pivotal role of FOXM1 in promoting metastasis of various cancer types. It also implicates the contribution of FOXM1 in the modulation of chemotherapeutic resistance, antitumor immune response/immunotherapies, and the potential of small molecule inhibitors of FOXM1.

Original language	English (US)
Pages (from-to)	1-15
Number of pages	15
Journal	Seminars in Cancer Biology
Volume	92
DOIs	https://doi.org/10.1016/j.semcancer.2023.03.007
State	Published - Jul 2023

Keywords

Chemoresistance
Metastasis
Recurrence
Subtype switching
Transcription factors

ASJC Scopus subject areas

Cancer Research

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10.1016/j.semcancer.2023.03.007

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title = "FOXM1: A small fox that makes more tracks for cancer progression and metastasis",

abstract = "Transcription factors (TFs) are indispensable for the modulation of various signaling pathways associated with normal cell homeostasis and disease conditions. Among cancer-related TFs, FOXM1 is a critical molecule that regulates multiple aspects of cancer cells, including growth, metastasis, recurrence, and stem cell features. FOXM1 also impact the outcomes of targeted therapies, chemotherapies, and immune checkpoint inhibitors (ICIs) in various cancer types. Recent advances in cancer research strengthen the cancer-specific role of FOXM1, providing a rationale to target FOXM1 for developing targeted therapies. This review compiles the recent studies describing the pivotal role of FOXM1 in promoting metastasis of various cancer types. It also implicates the contribution of FOXM1 in the modulation of chemotherapeutic resistance, antitumor immune response/immunotherapies, and the potential of small molecule inhibitors of FOXM1.",

keywords = "Chemoresistance, Metastasis, Recurrence, Subtype switching, Transcription factors",

author = "Khan, {Md Arafat} and Parvez Khan and Aatiya Ahmad and Mahek Fatima and Nasser, {Mohd Wasim}",

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year = "2023",

month = jul,

doi = "10.1016/j.semcancer.2023.03.007",

language = "English (US)",

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T2 - A small fox that makes more tracks for cancer progression and metastasis

AU - Khan, Md Arafat

AU - Khan, Parvez

AU - Ahmad, Aatiya

AU - Fatima, Mahek

AU - Nasser, Mohd Wasim

PY - 2023/7

Y1 - 2023/7

N2 - Transcription factors (TFs) are indispensable for the modulation of various signaling pathways associated with normal cell homeostasis and disease conditions. Among cancer-related TFs, FOXM1 is a critical molecule that regulates multiple aspects of cancer cells, including growth, metastasis, recurrence, and stem cell features. FOXM1 also impact the outcomes of targeted therapies, chemotherapies, and immune checkpoint inhibitors (ICIs) in various cancer types. Recent advances in cancer research strengthen the cancer-specific role of FOXM1, providing a rationale to target FOXM1 for developing targeted therapies. This review compiles the recent studies describing the pivotal role of FOXM1 in promoting metastasis of various cancer types. It also implicates the contribution of FOXM1 in the modulation of chemotherapeutic resistance, antitumor immune response/immunotherapies, and the potential of small molecule inhibitors of FOXM1.

AB - Transcription factors (TFs) are indispensable for the modulation of various signaling pathways associated with normal cell homeostasis and disease conditions. Among cancer-related TFs, FOXM1 is a critical molecule that regulates multiple aspects of cancer cells, including growth, metastasis, recurrence, and stem cell features. FOXM1 also impact the outcomes of targeted therapies, chemotherapies, and immune checkpoint inhibitors (ICIs) in various cancer types. Recent advances in cancer research strengthen the cancer-specific role of FOXM1, providing a rationale to target FOXM1 for developing targeted therapies. This review compiles the recent studies describing the pivotal role of FOXM1 in promoting metastasis of various cancer types. It also implicates the contribution of FOXM1 in the modulation of chemotherapeutic resistance, antitumor immune response/immunotherapies, and the potential of small molecule inhibitors of FOXM1.

KW - Chemoresistance

KW - Metastasis

KW - Recurrence

KW - Subtype switching

KW - Transcription factors

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DO - 10.1016/j.semcancer.2023.03.007

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JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

FOXM1: A small fox that makes more tracks for cancer progression and metastasis

Abstract

Keywords

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