Fracture-Resistant and Bioresorbable Drug-Eluting Poly(glycerol Sebacate) Coils

Kamyar Mollazadeh-Moghaddam, Hojatollah Rezaei Nejad, Ai Zheng Chen, Jie Ju, Ali Tamayol, Xiao Liu, Yu Shrike Zhang, Rahmi Oklu, Ali Khademhosseini

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Biodegradable drug-eluting stents (DESs) are used today to treat atherosclerotic arteries and as vehicles to deliver inhibitors to suppress restenosis, with potential applications also in localized cancer therapy. Here the development of a series of drug-eluting poly(glycerol sebacate) (PGS) coils that may find possible use as DESs is reported. PGS is a tough, biodegradable, and biocompatible elastomer that has adjustable mechanical properties thanks to careful control of the fabrication process. Specifically, 3D PGS coils featuring superior mechanical and fracture-resistance properties are fabricated. The surface erosion profile of PGS is designed to further reduce the risk of fragmentation and non-target embolization during the degradation process. A dual-encapsulation mechanism is applied, first poly(ε-caprolactone) microparticles loaded with an anticancer drug Doxorubicin followed by dispersion of these microparticles in the PGS coils, to prolong the release of drug molecules from the interior. Systematic evaluations of the mechanical properties of the PGS coils and their drug release behaviors are conducted. It is anticipated that, these PGS coils may enable minimally invasive delivery using standard endovascular catheters, for achieving localized and sustained release of chemotherapy to tumors, as well as conventional applications in treating vascular disorders.

Original languageEnglish (US)
Article number1800109
JournalAdvanced Therapeutics
Volume2
Issue number3
DOIs
StatePublished - Mar 2019

Keywords

  • bioresorbable
  • drug-eluting stents
  • fracture-resistant
  • localized therapy
  • poly(glycerol sebacate)

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Pharmaceutical Science
  • Genetics(clinical)
  • Biochemistry, medical
  • Pharmacology (medical)

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