Fragmentation of carbonyl oxides by N-oxides: An improved approach to alkene ozonolysis

Chris Schwartz, Joseph Raible, Kyle Mott, Patrick H. Dussault

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Ozonolysis of alkenes in the presence of amine N-oxides results in the direct formation of aldehydes. This reaction, which appears to involve an unprecedented trapping and fragmentation of the short-lived carbonyl oxide intermediates, avoids the hazards associated with generation and isolation of ozonides or other peroxide products.

Original languageEnglish (US)
Pages (from-to)3199-3201
Number of pages3
JournalOrganic Letters
Volume8
Issue number15
DOIs
StatePublished - Jul 20 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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