Free radicals and phagocytic cells

Gerald M. Rosen, Sovitj Pou, Carroll L. Ramos, Myron S. Cohen, Bradley E. Britigan

Research output: Contribution to journalReview article

384 Scopus citations

Abstract

Phagocytes mediate their innate immunological response by releasing products that damage invading microorganisms. These products include proteins such as lysozyme, peroxidases, and elastase as well as reactive oxygen species such as superoxide, hydrogen peroxide, hypohalous acid, and hydroxyl radical. Although it is dear that many phagocytic secretory products have direct cytotoxic potential, understanding is limited of how multiple products interact to generate and modulate the cytotoxic response. This review focuses on recent findings that elucidate the biochemical nature of secretory product interaction in the formation of free radicals, particularly the highly reactive hydroxyl radical. The possible role of these reactions in phagocyte microbicidal activity and inflammatory tissue injury is discussed.

Original languageEnglish (US)
Pages (from-to)200-209
Number of pages10
JournalFASEB Journal
Volume9
Issue number2
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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    Rosen, G. M., Pou, S., Ramos, C. L., Cohen, M. S., & Britigan, B. E. (1995). Free radicals and phagocytic cells. FASEB Journal, 9(2), 200-209. https://doi.org/10.1096/fasebj.9.2.7540156