Fried egg digest decreases blood pressure in spontaneous hypertensive rats

Kaustav Majumder; Sareh Panahi; Susan Kaufman; Jianping Wu

doi:10.1016/j.jff.2012.10.004

Fried egg digest decreases blood pressure in spontaneous hypertensive rats

Kaustav Majumder, Sareh Panahi, Susan Kaufman, Jianping Wu

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Our previous study showed that in vitro simulated gastrointestinal digestion of fried whole egg (FWE) released several peptides with angiotensin converting enzyme-I (ACE-I) inhibitory properties. The present study evaluated in vivo blood pressure lowering effect of FWE digest in spontaneously hypertensive rats (SHR). Twelve to fourteen weeks old male SHRs were surgically implanted with telemetric blood pressure (BP) measuring devices. After one week recovery, animals were randomly allocated to three groups at dosage of FWE digest 0 (control), 100, and 1000. mg of FWE digest/kg body weight for 3 days (n= 8), and the BP was recorded continuously. The 1000. mg/kg BW group showed a significant decrease in BP and also rectified the impaired circadian blood pressure rhythm compared to the control group. This study indicates a potential blood pressure lowering effect of egg consumption.

Original language	English (US)
Pages (from-to)	187-194
Number of pages	8
Journal	Journal of Functional Foods
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.jff.2012.10.004
State	Published - Jan 2013
Externally published	Yes

Keywords

Angiotensin converting enzyme-I inhibition
Blood pressure
Circadian rhythm
Fried whole egg digest
Spontaneously hypertensive rats

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

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10.1016/j.jff.2012.10.004

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title = "Fried egg digest decreases blood pressure in spontaneous hypertensive rats",

abstract = "Our previous study showed that in vitro simulated gastrointestinal digestion of fried whole egg (FWE) released several peptides with angiotensin converting enzyme-I (ACE-I) inhibitory properties. The present study evaluated in vivo blood pressure lowering effect of FWE digest in spontaneously hypertensive rats (SHR). Twelve to fourteen weeks old male SHRs were surgically implanted with telemetric blood pressure (BP) measuring devices. After one week recovery, animals were randomly allocated to three groups at dosage of FWE digest 0 (control), 100, and 1000. mg of FWE digest/kg body weight for 3 days (n= 8), and the BP was recorded continuously. The 1000. mg/kg BW group showed a significant decrease in BP and also rectified the impaired circadian blood pressure rhythm compared to the control group. This study indicates a potential blood pressure lowering effect of egg consumption.",

keywords = "Angiotensin converting enzyme-I inhibition, Blood pressure, Circadian rhythm, Fried whole egg digest, Spontaneously hypertensive rats",

author = "Kaustav Majumder and Sareh Panahi and Susan Kaufman and Jianping Wu",

note = "Funding Information: This research was funded by grants from Egg Farmers of Canada (EFC), Egg Farmers of Alberta (EFA), the Agriculture and Food Council, which is responsible for delivering Agriculture and Agri-Food Canada{\textquoteright}s Canadian Agricultural Adaptation Program (CAAP) Program in Alberta, and Natural Sciences and Engineering Research Council (NSERC) of Canada to J. Wu. ",

year = "2013",

month = jan,

doi = "10.1016/j.jff.2012.10.004",

language = "English (US)",

volume = "5",

pages = "187--194",

journal = "Journal of Functional Foods",

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T1 - Fried egg digest decreases blood pressure in spontaneous hypertensive rats

AU - Majumder, Kaustav

AU - Panahi, Sareh

AU - Kaufman, Susan

AU - Wu, Jianping

N1 - Funding Information: This research was funded by grants from Egg Farmers of Canada (EFC), Egg Farmers of Alberta (EFA), the Agriculture and Food Council, which is responsible for delivering Agriculture and Agri-Food Canada’s Canadian Agricultural Adaptation Program (CAAP) Program in Alberta, and Natural Sciences and Engineering Research Council (NSERC) of Canada to J. Wu.

PY - 2013/1

Y1 - 2013/1

N2 - Our previous study showed that in vitro simulated gastrointestinal digestion of fried whole egg (FWE) released several peptides with angiotensin converting enzyme-I (ACE-I) inhibitory properties. The present study evaluated in vivo blood pressure lowering effect of FWE digest in spontaneously hypertensive rats (SHR). Twelve to fourteen weeks old male SHRs were surgically implanted with telemetric blood pressure (BP) measuring devices. After one week recovery, animals were randomly allocated to three groups at dosage of FWE digest 0 (control), 100, and 1000. mg of FWE digest/kg body weight for 3 days (n= 8), and the BP was recorded continuously. The 1000. mg/kg BW group showed a significant decrease in BP and also rectified the impaired circadian blood pressure rhythm compared to the control group. This study indicates a potential blood pressure lowering effect of egg consumption.

AB - Our previous study showed that in vitro simulated gastrointestinal digestion of fried whole egg (FWE) released several peptides with angiotensin converting enzyme-I (ACE-I) inhibitory properties. The present study evaluated in vivo blood pressure lowering effect of FWE digest in spontaneously hypertensive rats (SHR). Twelve to fourteen weeks old male SHRs were surgically implanted with telemetric blood pressure (BP) measuring devices. After one week recovery, animals were randomly allocated to three groups at dosage of FWE digest 0 (control), 100, and 1000. mg of FWE digest/kg body weight for 3 days (n= 8), and the BP was recorded continuously. The 1000. mg/kg BW group showed a significant decrease in BP and also rectified the impaired circadian blood pressure rhythm compared to the control group. This study indicates a potential blood pressure lowering effect of egg consumption.

KW - Angiotensin converting enzyme-I inhibition

KW - Blood pressure

KW - Circadian rhythm

KW - Fried whole egg digest

KW - Spontaneously hypertensive rats

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JO - Journal of Functional Foods

JF - Journal of Functional Foods

IS - 1

ER -

Fried egg digest decreases blood pressure in spontaneous hypertensive rats

Abstract

Keywords

ASJC Scopus subject areas

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