From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme

Samantha A. Swenson, Courtney M. Moore, Jason R. Marcero, Amy E. Medlock, Amit R. Reddi, Oleh Khalimonchuk

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme-a highly reactive and inherently toxic compound-and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria.

Original languageEnglish (US)
JournalCells
Volume9
Issue number3
DOIs
StatePublished - Feb 29 2020

Keywords

  • heme
  • heme biosynthesis
  • hemoproteins
  • membrane transporters
  • mitochondria
  • porphyrin

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme'. Together they form a unique fingerprint.

Cite this