TY - JOUR
T1 - Fulminant hepatic failure and orthotopic liver transplantation
AU - Schafer, D. F.
AU - Shaw, B. W.
PY - 1989
Y1 - 1989
N2 - Twenty-four patients were transplanted for fulminant hepatic failure at the University of Nebraska Medical Center from 1986 (July) to 1988. Long-term survival is about 58%. FHF is an increasingly common indication for liver transplantation. Cerebral edema, organ availability, and late referral are obstacles to improved survival. Randomized trials have not been performed to demonstrate that transplantation is superior toother therapies. For some etiologies, such as acute Wilson's disease, in which mortality is 100%, transplantation is clearly indicated. For other etiologies, such as acetaminophen-induced FHF, in which clear gains in survival have been shown using more conservative therapies, the decision to transplant patients becomes more difficult. As all forms of therapy improve, all patients will benefit.
AB - Twenty-four patients were transplanted for fulminant hepatic failure at the University of Nebraska Medical Center from 1986 (July) to 1988. Long-term survival is about 58%. FHF is an increasingly common indication for liver transplantation. Cerebral edema, organ availability, and late referral are obstacles to improved survival. Randomized trials have not been performed to demonstrate that transplantation is superior toother therapies. For some etiologies, such as acute Wilson's disease, in which mortality is 100%, transplantation is clearly indicated. For other etiologies, such as acetaminophen-induced FHF, in which clear gains in survival have been shown using more conservative therapies, the decision to transplant patients becomes more difficult. As all forms of therapy improve, all patients will benefit.
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U2 - 10.1055/s-2008-1040512
DO - 10.1055/s-2008-1040512
M3 - Review article
C2 - 2683105
AN - SCOPUS:0024446468
VL - 9
SP - 189
EP - 194
JO - Seminars in Liver Disease
JF - Seminars in Liver Disease
SN - 0272-8087
IS - 3
ER -