@article{35fc856c552541ccb9f573a43a0a8a1b,
title = "Functional and quantitative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on the cell-mediated immune system in mice",
author = "Jackson, {J. D.} and Sharp, {J. G.}",
note = "Funding Information: This study evaluates the effects of TCDD exposure on cell-mediated immune function and on T-cell subpopulations using indirect fluorescent staining with mono~lonal antibodies to specific T-cell surface-markers and flow cytometry. Female C57BI/6J mice were dosed weekly for 2 weeks by gastric intubation with 5 Mg/kg TCDD dissolved in 6 parts corn oil and 1 part acetone. Control animals were given the corn oil-acetone mixture only or were untreated. One week following the last dose of TCDD, the mice were evaluated for ~une function utilizing mitngen, hemolytic plaque, and delayed type hypersensitivity (DTH) assays. The data indicate an overall decrease in spleen cell number and thymus weight in the TCDD-treated group with no apparent differences in the relative T-cell subpopulation frequencies in the spleen cell population. There also appears to be a decreased or suppression of spleen oell-medlated function as measured by mitngen, hemolytic plaque, and DTH assays. One may speculate that non-functional T-cell populations, not yet fully mature and in a regenerative phase are present in the spleen, or there is a specific suppressor cell population that has been generated during the treatment with TCDD. (Supported in part by UHMC Seed Grant funds.)",
year = "1982",
doi = "10.1016/0192-0561(82)90278-8",
language = "English (US)",
volume = "4",
pages = "323",
journal = "International Immunopharmacology",
issn = "1567-5769",
publisher = "Elsevier",
number = "4",
}