Functional genomic insights into regulatory mechanisms of high-altitude adaptation

Jay F. Storz, Zachary A. Cheviron

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Recent studies of indigenous human populations at high altitude have provided proof-ofprinciple that genome scans of DNA polymorphism can be used to identify candidate loci for hypoxia adaptation. When integrated with experimental analyses of physiological phenotypes, genome-wide surveys of DNA polymorphism and tissue-specifi c transcriptional profi les can provide insights into actual mechanisms of adaptation. It has been suggested that adaptive phenotypic evolution is largely mediated by cis -regulatory changes in genes that are located at integrative control points in regulatory networks. This hypothesis can be tested by conducting transcriptomic analyses of hypoxic signaling pathways in conjunction with experimental measures of vascular oxygen supply and metabolic pathway fl ux. Such studies may reveal whether the architecture of gene regulatory networks can be used to predict which loci (and which types of loci) are likely to be “hot spots” for adaptive phy siological evolution. Functional genomic studies of deer mice ( Peromyscus maniculatus ) demonstrate how the integrated analysis of variation in tissue-specifi c transcriptomes, whole-animal physiological performance, and various subordinate traits can yield insights into the mechanistic underpinnings of highaltitude adaptation.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages113-128
Number of pages16
DOIs
StatePublished - 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume903
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Functional genomics
  • Hypoxia
  • Peromyscus
  • Population genomics
  • Systems genetics
  • Transcriptomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Storz, J. F., & Cheviron, Z. A. (2016). Functional genomic insights into regulatory mechanisms of high-altitude adaptation. In Advances in Experimental Medicine and Biology (pp. 113-128). (Advances in Experimental Medicine and Biology; Vol. 903). Springer New York LLC. https://doi.org/10.1007/978-1-4899-7678-9_8