Functional genomics and NMR spectroscopy

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

The recent success of the human genome project and the continued accomplishment in obtaining DNA sequences for a vast array of organisms is providing an unprecedented wealth of information. Nevertheless, an abundance of the proteome contains hypothetical proteins or proteins of unknown function, where high throughput approaches for genome-wide functional annotation (functional genomics) has evolved as the necessary next step. Nuclear magnetic resonance spectroscopy is playing an important role in functional genomics by providing information on the structure of protein and protein-ligand complexes, from metabolite fingerprinting and profiling, from the analysis of the metabolome, and from ligand affinity screens to identify chemical probes.

Original languageEnglish (US)
Pages (from-to)676-697
Number of pages22
JournalCombinatorial Chemistry and High Throughput Screening
Volume10
Issue number8
DOIs
StatePublished - Sep 2007

Keywords

  • Chemical proteomics
  • Functional genomics
  • Hypothetical proteins
  • NMR
  • NMR high throughput screens
  • NMR metabolomics
  • Protein structure initiative
  • Protein-ligand binding
  • Protein-ligand co-structures
  • Structural biology
  • Structural genomics

ASJC Scopus subject areas

  • Drug Discovery
  • Computer Science Applications
  • Organic Chemistry

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