Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder

Hans C. Breiter, Scott L. Rauch, Kenneth K. Kwong, John R. Baker, Robert M. Weisskoff, David N. Kennedy, Adair D. Kendrick, Timothy L. Davis, Aiping Jiang, Mark S. Cohen, Chantal E. Stern, John W. Belliveau, Lee Baer, Richard L. O'Sullivan, Cary R. Savage, Michael A. Jenike, Bruce R. Rosen

Research output: Contribution to journalArticlepeer-review

553 Scopus citations


Background: The new technique of functional magnetic resonance imaging was used to investigate the mediating neuroanatomy of obsessive-compulsive disorder symptoms. Methods: Ten patients with obsessive-compulsive disorder and 5 normal subjects were studied via functional magnetic resonance imaging during control and provoked conditions. Data analysis entailed parametric and nonparametric statistical mapping. Results: Statistical maps (nonparametric; P<10-3) showed activation for 70% or more of patients with obsessive- compulsive disorder in medial orbitofrontal, lateral frontal, anterior temporal, anterior cingulate, and insular cortex, as well as caudate, lenticulate, and amygdala. No normal subjects exhibited activation in any brain region. Conclusions: Results of functional magnetic resonance imaging were consistent with past studies of obsessive-compulsive disorder that used other functional neuroimaging modalities. However, paralimbic and limbic activations were more prominent in the present study.

Original languageEnglish (US)
Pages (from-to)595-606
Number of pages12
JournalArchives of general psychiatry
Issue number7
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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