Functional neuroimaging and cognitive rehabilitation for people with traumatic brain injury

Gary Strangman, Therese M. O'Neil-Pirozzi, David Burke, Dana Cristina, Richard Goldstein, Scott L. Rauch, Cary R. Savage, Mel B. Glenn

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations


Cognitive deficits are a common consequence of traumatic brain injury. Although such deficits are amenable to rehabilitation, methods for individualizing cognitive interventions are still unrefined. Functional neuroimaging methods such as positron emission tomography and functional magnetic resonance imaging are emerging as possible technologies for measuring and monitoring the cerebral consequences of plasticity associated with brain injury and for evaluating the effectiveness of rehabilitation interventions. Functional neuroimaging may even enable more customized and efficient selection, design, or adaptation of individual cognitive rehabilitation programs. We review the current literature on functional neuroimaging after traumatic brain injury, relating these findings to cognitive rehabilitation. Overall, functional neuroimaging after traumatic brain injury has shown reliable differences in brain activity within several regions of frontal cortex, partly but not uniformly consistent with neuropsychological and structural findings in traumatic brain injury. We also outline a number of promising research opportunities for applying functional neuroimaging in traumatic brain injury settings, along with associated challenges.

Original languageEnglish (US)
Pages (from-to)62-75
Number of pages14
JournalAmerican Journal of Physical Medicine and Rehabilitation
Issue number1
StatePublished - Jan 2005
Externally publishedYes


  • Cognitive Rehabilitation
  • Functional Magnetic Resonance Imaging
  • Functional Neuroimaging
  • Hemodynamic
  • Review
  • Traumatic Brain Injury

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


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