Functional properties of human auditory cortical fields

David L. Woods, Timothy J. Herron, Anthony D. Cate, E. William Yund, G. Christopher Stecker, Teemu Rinne, X. Kang

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

While auditory cortex in non-human primates has been subdivided into multiple functionally specialized auditory cortical fields (ACFs), the boundaries and functional specialization of human ACFs have not been defined. In the current study, we evaluated whether a widely accepted primate model of auditory cortex could explain regional tuning properties of fMRI activations on the cortical surface to attended and non-attended tones of different frequency, location, and intensity. The limits of auditory cortex were defined by voxels that showed significant activations to non-attended sounds. Three centrally located fields with mirror-symmetric tonotopic organization were identified and assigned to the three core fields of the primate model while surrounding activations were assigned to belt fields following procedures similar to those used in macaque fMRI studies. The functional properties of core, medial belt, and lateral belt field groups were then analyzed. Field groups were distinguished by tonotopic organization, frequency selectivity, intensity sensitivity, contralaterality, binaural enhancement, attentional modulation, and hemispheric asymmetry. In general, core fields showed greater sensitivity to sound properties than did belt fields, while belt fields showed greater attentional modulation than core fields. Significant distinctions in intensity sensitivity and contralaterality were seen between adjacent core fields A1 and R, while multiple differences in tuning properties were evident at boundaries between adjacent core and belt fields. The reliable differences in functional properties between fields and field groups suggest that the basic primate pattern of auditory cortex organization is preserved in humans. A comparison of the sizes of functionally defined ACFs in humans and macaques reveals a significant relative expansion in human lateral belt fields implicated in the processing of speech.

Original languageEnglish (US)
Article number155
JournalFrontiers in Systems Neuroscience
Volume4
DOIs
StatePublished - 2010

Keywords

  • Attention
  • Cortical mapping
  • Fmri
  • Primate
  • Sound intensity
  • Sound location
  • Tones
  • Tonotopy

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Functional properties of human auditory cortical fields'. Together they form a unique fingerprint.

  • Cite this

    Woods, D. L., Herron, T. J., Cate, A. D., Yund, E. W., Stecker, G. C., Rinne, T., & Kang, X. (2010). Functional properties of human auditory cortical fields. Frontiers in Systems Neuroscience, 4, [155]. https://doi.org/10.3389/fnsys.2010.00155