Functional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission

Hong Zhang, Marzena Rola, John T. West, Damien C. Tully, Piotr Kubis, Jun He, Chipepo Kankasa, Charles Wood

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Understanding the properties of viruses capable of establishing infection during perinatal transmission of HIV-1 is critical for designing effective means of limiting transmission. We previously demonstrated that the newly transmitted viruses (in infant) were more fit in growth, as imparted by their envelope glycoproteins, than those in their corresponding mothers. Here, we further characterized the viral envelope glycoproteins from six mother-infant transmission pairs and determined whether any specific envelope functions correlate with HIV-1 subtype C perinatal transmission. We found that most newly transmitted viruses were less susceptible to neutralization by their maternal plasma compared to contemporaneous maternal viruses. However, the newly transmitted variants were sensitive to neutralization by pooled heterologous plasma but in general were resistant to IgG1 b12. Neither Env processing nor incorporation efficiency was predictive of viral transmissibility. These findings provide further insight into the characteristics of perinatally transmissible HIV-1 and may have implications for intervention approaches.

Original languageEnglish (US)
Pages (from-to)164-174
Number of pages11
JournalVirology
Volume400
Issue number2
DOIs
StatePublished - May 2010

Keywords

  • Autologous or heterologous antibodies
  • Envelope glycoproteins
  • Envelope processing and incorporation
  • HIV-1 subtype C
  • Neutralization
  • Perinatal transmission

ASJC Scopus subject areas

  • Virology

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