Functional roles of p120ctn family of proteins in central neurons

Li Yuan, Jyothi Arikkath

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The cadherin-catenin complex in central neurons is associated with a variety of cytosolic partners, collectively called catenins. The p120ctn members are a family of catenins that are distinct from the more ubiquitously expressed α- and β-catenins. It is becoming increasingly clear that the functional roles of the p120ctn family of catenins in central neurons extend well beyond their functional roles in non-neuronal cells in partnering with cadherin to regulate adhesion. In this review, we will provide an overview of the p120ctn family in neurons and their varied functional roles in central neurons. Finally, we will examine the emerging roles of this family of proteins in neurodevelopmental disorders.

Original languageEnglish (US)
Pages (from-to)70-82
Number of pages13
JournalSeminars in Cell and Developmental Biology
Volume69
DOIs
StatePublished - Sep 2017

Keywords

  • ARVCF
  • Neuron
  • p0071
  • p120ctn
  • δ-catenin

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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