Functions of autophagy in normal and diseased liver

Mark J. Czaja, Wen Xing Ding, Terrence M. Donohue, Scott L. Friedman, Jae Sung Kim, Masaaki Komatsu, John J. Lemasters, Antoinette Lemoine, Jiandie D. Lin, Jing Hsiung James Ou, David H. Perlmutter, Glenn Randall, Ratna B. Ray, Allan Tsung, Xiao Ming Yin

Research output: Contribution to journalReview article

232 Scopus citations

Abstract

Autophagy has emerged as a critical lysosomal pathway that maintains cell function and survival through the degradation of cellular components such as organelles and proteins. Investigations specifically employing the liver or hepatocytes as experimental models have contributed significantly to our current knowledge of autophagic regulation and function. The diverse cellular functions of autophagy, along with unique features of the liver and its principal cell type the hepatocyte, suggest that the liver is highly dependent on autophagy for both normal function and to prevent the development of disease states. However, instances have also been identified in which autophagy promotes pathological changes such as the development of hepatic fibrosis. Considerable evidence has accumulated that alterations in autophagy are an underlying mechanism of a number of common hepatic diseases including toxin-, drug- and ischemia/reperfusion-induced liver injury, fatty liver, viral hepatitis and hepatocellular carcinoma. This review summarizes recent advances in understanding the roles that autophagy plays in normal hepatic physiology and pathophysiology with the intent of furthering the development of autophagy-based therapies for human liver diseases.

Original languageEnglish (US)
Pages (from-to)1131-1158
Number of pages28
JournalAutophagy
Volume9
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • Autophagy
  • Drug toxicity
  • Hepatitis
  • Hepatocellular carcinoma
  • Hepatocyte
  • Hepatotoxin
  • Ischemia/reperfusion
  • Liver
  • Liver injury

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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  • Cite this

    Czaja, M. J., Ding, W. X., Donohue, T. M., Friedman, S. L., Kim, J. S., Komatsu, M., Lemasters, J. J., Lemoine, A., Lin, J. D., Ou, J. H. J., Perlmutter, D. H., Randall, G., Ray, R. B., Tsung, A., & Yin, X. M. (2013). Functions of autophagy in normal and diseased liver. Autophagy, 9(8), 1131-1158. https://doi.org/10.4161/auto.25063