Fundus autofluorescence imaging: Fundamentals and clinical relevance

Yasir J. Sepah, Abeer Akhtar, Mohammad Ali Sadiq, Yamama Hafeez, Humzah Nasir, Brian Perez, Narissa Mawji, Diana J. Dean, Daniel Ferraz, Quan Dong Nguyen

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Fundus autofluorescence (FAF), a relatively new imaging modality, focuses on the fluorescent properties of pigments in the retina to generate images that help us view various disease processes from a different perspective. It aids us in the understanding of the pathophysiology of different retinal disorders. Recently, FAF imaging is being used commonly to help us in the diagnosis, prognosis as well as in determining the treatment response of various retinal disorders. It generates an image based on the distribution pattern of a fluorescent pigment called lipofuscin. Knowing the distribution pattern of lipofuscin in the normal retina is key to understanding an FAF image representing a retinal pathology. Like most other imaging modalities, FAF comes with its own limitations, taking steps to overcome these limitations will be of utmost importance in using this imaging modality to its fullest potential.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalSaudi Journal of Ophthalmology
Issue number2
StatePublished - Apr 2014


  • Fundus autofluorescence
  • Imaging
  • Retina

ASJC Scopus subject areas

  • Ophthalmology


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