Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor

J. A. Bridge; M. Kanamori; Z. Ma; D. Pickering; D. A. Hill; W. Lydiatt; M. Y. Lui; G. W B Colleoni; C. R. Antonescu; M. Ladanyi; S. W. Morris

doi:10.1016/S0002-9440(10)61711-7

Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor

J. A. Bridge, M. Kanamori, Z. Ma, D. Pickering, D. A. Hill, W. Lydiatt, M. Y. Lui, G. W B Colleoni, C. R. Antonescu, M. Ladanyi, S. W. Morris

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310 Scopus citations

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. In a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46, XX, t(2;17)(p23;q23), add(16)(q24)].

Original language	English (US)
Pages (from-to)	411-415
Number of pages	5
Journal	American Journal of Pathology
Volume	159
Issue number	2
DOIs	https://doi.org/10.1016/S0002-9440(10)61711-7
State	Published - 2001

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/S0002-9440(10)61711-7

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@article{dcacf457d0c44698a8d3f8363c53c20b,

title = "Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor",

abstract = "Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. In a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46, XX, t(2;17)(p23;q23), add(16)(q24)].",

author = "Bridge, {J. A.} and M. Kanamori and Z. Ma and D. Pickering and Hill, {D. A.} and W. Lydiatt and Lui, {M. Y.} and Colleoni, {G. W B} and Antonescu, {C. R.} and M. Ladanyi and Morris, {S. W.}",

note = "Funding Information: Supported by National Cancer Institute grants NCI-P30 CA36727 , the John A. Wiebe Jr. Children's Health Care Fund and National Childhood Cancer Foundation (to J. A. B.), National Cancer Institute grant NCI CA69129 and CORE grant CA21765 (to S. W. M.), the American Lebanese Syrian Associated Charities, the St. Jude Children's Hospital (to S. W. M.), and the Funda{\c c}ao de Amparo {\`a} Pesquisa do Estado de Sao Paulo (to G. W. B. C.). ",

year = "2001",

doi = "10.1016/S0002-9440(10)61711-7",

language = "English (US)",

volume = "159",

pages = "411--415",

journal = "American Journal of Pathology",

issn = "0002-9440",

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TY - JOUR

T1 - Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor

AU - Bridge, J. A.

AU - Kanamori, M.

AU - Ma, Z.

AU - Pickering, D.

AU - Hill, D. A.

AU - Lydiatt, W.

AU - Lui, M. Y.

AU - Colleoni, G. W B

AU - Antonescu, C. R.

AU - Ladanyi, M.

AU - Morris, S. W.

N1 - Funding Information: Supported by National Cancer Institute grants NCI-P30 CA36727 , the John A. Wiebe Jr. Children's Health Care Fund and National Childhood Cancer Foundation (to J. A. B.), National Cancer Institute grant NCI CA69129 and CORE grant CA21765 (to S. W. M.), the American Lebanese Syrian Associated Charities, the St. Jude Children's Hospital (to S. W. M.), and the Fundaçao de Amparo à Pesquisa do Estado de Sao Paulo (to G. W. B. C.).

PY - 2001

Y1 - 2001

N2 - Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. In a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46, XX, t(2;17)(p23;q23), add(16)(q24)].

AB - Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. In a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46, XX, t(2;17)(p23;q23), add(16)(q24)].

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Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor

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