G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells

Hong Xin, Rongze Lu, Heehyoung Lee, Wang Zhang, Chunyan Zhang, Jiehui Deng, Yong Liu, Shudan Shen, Kay Uwe Wagner, Stephen Forman, Richard Jove, Hua Yu

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background: Signaling pathways underlying BV8-mediated oncogenesis remain unknown. Results: BV8-STAT3 forms a feed-forward loop in both normal and malignant myeloid cells and promotes tumor growth. Conclusion: JAK2/STAT3 signaling plays critical roles in BV8-mediated myeloid cell-dependent oncogenesis. Significance: This study identifies a novel role of BV8-STAT3 signaling in mediating cross-talk between tumor microenvironment and tumor cells.

Original languageEnglish (US)
Pages (from-to)13842-13849
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number19
DOIs
StatePublished - May 10 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Xin, H., Lu, R., Lee, H., Zhang, W., Zhang, C., Deng, J., Liu, Y., Shen, S., Wagner, K. U., Forman, S., Jove, R., & Yu, H. (2013). G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells. Journal of Biological Chemistry, 288(19), 13842-13849. https://doi.org/10.1074/jbc.M113.450049