GABAB Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K+ Channels

Pan Yue Deng, Zhaoyang Xiao, Chuanxiu Yang, Lalida Rojanathammanee, Laurel Grisanti, John Watt, Jonathan D. Geiger, Rugao Liu, James E. Porter, Saobo Lei

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

The entorhinal cortex (EC) is regarded as the gateway to the hippocampus and thus is essential for learning and memory. Whereas the EC expresses a high density of GABAB receptors, the functions of these receptors in this region remain unexplored. Here, we examined the effects of GABAB receptor activation on neuronal excitability in the EC and spatial learning. Application of baclofen, a specific GABAB receptor agonist, inhibited significantly neuronal excitability in the EC. GABAB receptor-mediated inhibition in the EC was mediated via activating TREK-2, a type of two-pore domain K+ channels, and required the functions of inhibitory G proteins and protein kinase A pathway. Depression of neuronal excitability in the EC underlies GABAB receptor-mediated inhibition of spatial learning as assessed by Morris water maze. Our study indicates that GABAB receptors exert a tight control over spatial learning by modulating neuronal excitability in the EC.

Original languageEnglish (US)
Pages (from-to)230-243
Number of pages14
JournalNeuron
Volume63
Issue number2
DOIs
StatePublished - Jul 30 2009

Keywords

  • MOLNEURO
  • SYSBIO
  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

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    Deng, P. Y., Xiao, Z., Yang, C., Rojanathammanee, L., Grisanti, L., Watt, J., Geiger, J. D., Liu, R., Porter, J. E., & Lei, S. (2009). GABAB Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K+ Channels. Neuron, 63(2), 230-243. https://doi.org/10.1016/j.neuron.2009.06.022