TY - JOUR
T1 - Gait variability patterns are altered in healthy young individuals during the acute reperfusion phase of ischemia-reperfusion
AU - Myers, Sara A.
AU - Stergiou, Nick
AU - Pipinos, Iraklis I.
AU - Johanning, Jason M.
N1 - Funding Information:
This work was supported by funds received from the American Geriatrics Society's Hartford Foundation Dennis W. Jahnigen Award (to JMJ), the Nebraska Research Initiative (to NS), the American Society of Biomechanics, the American Alliance for Health, Physical Education, Recreation, and Dance Research Grant program, National Institute On Aging (Award Number F31AG032788), and the NASA Nebraska Space Grant Fellowship (to SM).
PY - 2010/11
Y1 - 2010/11
N2 - Background: The role of ischemia reperfusion contributing to functional impairment in lower extremity peripheral arterial disease (PAD) patients has not previously been elucidated. The evaluation of gait variability patterns has proven useful in many pathologic populations. Therefore, the purpose of this study is to isolate and determine the specific effect of the acute reperfusion phase of ischemia-reperfusion on gait variability in young individuals with no vascular disease. Materials and Methods: Thirty healthy young individuals walked on a treadmill during baseline and the acute reperfusion phase of ischemia-reperfusion conditions while lower extremity joint kinematics were captured. Stride to stride variability was assessed using the largest Lyapunov exponent, approximate entropy, standard deviation, and coefficient of variation. Differences in gait variability between conditions were assessed using dependent t-tests. Results: The largest Lyapunov exponent values and approximate entropy values were significantly higher in the acute reperfusion phase of ischemia-reperfusion condition for the ankle, knee, and the hip. Coefficient of variation was significantly higher at the hip and standard deviation was higher at the knee and the hip during the acute reperfusion phase of ischemia-reperfusion condition. Conclusions: The acute reperfusion phase of the ischemia-reperfusion cycle alters gait variability patterns at the ankle, knee, and the hip in healthy young individuals. Our findings indicate increased noise and irregularity of gait variability patterns post-ischemia. In young healthy individuals who do not have neuromuscular impairments, significant gait alterations are present during walking after a period of interruption of blood flow.
AB - Background: The role of ischemia reperfusion contributing to functional impairment in lower extremity peripheral arterial disease (PAD) patients has not previously been elucidated. The evaluation of gait variability patterns has proven useful in many pathologic populations. Therefore, the purpose of this study is to isolate and determine the specific effect of the acute reperfusion phase of ischemia-reperfusion on gait variability in young individuals with no vascular disease. Materials and Methods: Thirty healthy young individuals walked on a treadmill during baseline and the acute reperfusion phase of ischemia-reperfusion conditions while lower extremity joint kinematics were captured. Stride to stride variability was assessed using the largest Lyapunov exponent, approximate entropy, standard deviation, and coefficient of variation. Differences in gait variability between conditions were assessed using dependent t-tests. Results: The largest Lyapunov exponent values and approximate entropy values were significantly higher in the acute reperfusion phase of ischemia-reperfusion condition for the ankle, knee, and the hip. Coefficient of variation was significantly higher at the hip and standard deviation was higher at the knee and the hip during the acute reperfusion phase of ischemia-reperfusion condition. Conclusions: The acute reperfusion phase of the ischemia-reperfusion cycle alters gait variability patterns at the ankle, knee, and the hip in healthy young individuals. Our findings indicate increased noise and irregularity of gait variability patterns post-ischemia. In young healthy individuals who do not have neuromuscular impairments, significant gait alterations are present during walking after a period of interruption of blood flow.
KW - atherosclerosis
KW - peripheral arterial disease
KW - peripheral vascular disease
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U2 - 10.1016/j.jss.2010.04.030
DO - 10.1016/j.jss.2010.04.030
M3 - Article
C2 - 20828731
AN - SCOPUS:77958089002
SN - 0022-4804
VL - 164
SP - 6
EP - 12
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 1
ER -