Abstract
Prompted by the notion that the membrane channels in gap junctions conduct growth-regulating signals from cell to cell, we transferred the α1 gene for the channel protein (connexin43) of rat heart to tumorigenic mouse MCA-10 cells. Upon incorporation into the cell genome, this exogenous gene was expressed, resulting in functional channels and normal growth regulation: cell-cell communication, determined with a channel-permeant 400-dalton fluorescent tracer, was increased and tumorigenicity, determined in nude mice, was suppressed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1073-1075 |
| Number of pages | 3 |
| Journal | Carcinogenesis |
| Volume | 14 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1993 |
ASJC Scopus subject areas
- Cancer Research
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Rose, B., Mehta, P. P., & Loewenstein, W. R. (1993). Gap-junction protein gene suppresses tumorigenicity. Carcinogenesis, 14(5), 1073-1075. https://doi.org/10.1093/carcin/14.5.1073