Abstract
Prompted by the notion that the membrane channels in gap junctions conduct growth-regulating signals from cell to cell, we transferred the α1 gene for the channel protein (connexin43) of rat heart to tumorigenic mouse MCA-10 cells. Upon incorporation into the cell genome, this exogenous gene was expressed, resulting in functional channels and normal growth regulation: cell-cell communication, determined with a channel-permeant 400-dalton fluorescent tracer, was increased and tumorigenicity, determined in nude mice, was suppressed.
Original language | English (US) |
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Pages (from-to) | 1073-1075 |
Number of pages | 3 |
Journal | Carcinogenesis |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - May 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Cancer Research