Gap-junction protein gene suppresses tumorigenicity

Birgit Rose, Parmender P. Mehta, Werner R. Loewenstein

Research output: Contribution to journalArticle

166 Scopus citations

Abstract

Prompted by the notion that the membrane channels in gap junctions conduct growth-regulating signals from cell to cell, we transferred the α1 gene for the channel protein (connexin43) of rat heart to tumorigenic mouse MCA-10 cells. Upon incorporation into the cell genome, this exogenous gene was expressed, resulting in functional channels and normal growth regulation: cell-cell communication, determined with a channel-permeant 400-dalton fluorescent tracer, was increased and tumorigenicity, determined in nude mice, was suppressed.

Original languageEnglish (US)
Pages (from-to)1073-1075
Number of pages3
JournalCarcinogenesis
Volume14
Issue number5
DOIs
StatePublished - May 1993

ASJC Scopus subject areas

  • Cancer Research

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    Rose, B., Mehta, P. P., & Loewenstein, W. R. (1993). Gap-junction protein gene suppresses tumorigenicity. Carcinogenesis, 14(5), 1073-1075. https://doi.org/10.1093/carcin/14.5.1073